In Ghana, like much of Africa, infectious diseases remain a major public health problem, with devastating social and economic impact. Infant mortality (50 per 1,000 live births) remains high, and fewer than 30% of children sleep under malaria preventing bed nets. Approximately 140,000 women of childbearing age in Ghana are living with HIV, and most infected women do not receive medicines to prevent transmission of HIV to their newborn babies. Sanitation is poor, especially in rural areas, and children are at high risk of parasitic diseases that cause anemia and malnutrition. HopeXchange Medical Center will coordinate activities designed to reduce the burden of infectious diseases among the most vulnerable populations. The Maternal-Child Health Center will include a perinatal clinic that will provide comprehensive screening and treatment for HIV, malaria, and parasitic diseases, which will improve birth outcomes and give children the best possible start in life. The inpatient service will provide care to those with advanced HIV/AIDS or severe malaria, including complex cases of drug resistant disease. Research projects will focus on defining the burden of infectious diseases in Kumasi and the greater Ashanti region, with a goal of developing and testing community based interventions in collaboration with local Ministry of Health officials.